Immunity and the constant construction and maintenance of biological boundaries

Recent data show that the immune system is not just a system of elimination and defence, but is involved, much more broadly, in development, regulation, and repair. One key problem is to determine how the immune system constantly patrols and repairs biological boundaries, such as the epithelium and the endothelium. We are particularly interested in how innate lymphoid cells (ILCs) and gammadelta T cells are involved in this process. We are developing, with Patrick Blanco’s group, a translational program exploring the role of ILC2s in controlling and maintaining the endothelium, both in physiological and pathological conditions, including in fibrosis and systemic sclerosis.

People involved in Bordeaux: Patrick Blanco, Cécile Contin-Bordes, Julie Déchanet-Merville, Paôline Laurent (PhD student), Valérie Jolivel (postdoc), Pauline Manicki, Jean-François Moreau, Thomas Pradeu, Marie-Elise Truchetet.

PI: Thomas Pradeu

This project is funded by the IDEX programme of the University of Bordeaux and Thomas Pradeu’s group at ImmunoConcept.