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Mina Bissell (Berkeley) Why Don’t We Get More Cancer: The tales of ECM and p53 signaling

21 September 2017 | 14 h 00 min - 15 h 00 min

Title: “Why Don’t We Get More Cancer: The tales of ECM and p53 signaling”

Abstract:

Research in the last three decades has been focused on the crucial role of extracellular matrix (ECM), and in particular laminin 111, as fundamental regulators in breast cancer. This molecule plays an extremely important role in organ- and tissue- specificity and form and function. The ECM of each tissue dictates how normal remains normal and how aberration in its components or the loss of laminins will eventually lead to genomic instability and cancer.
I will discuss, the important role of laminin and its receptors in drug resistance and therapy. Our current data connect laminin1 and laminin5 to regulation of p53 and many other transcription factors in physiologically relevant 3D models.
Finally, our current findings indicate a direct mechanical connection between the ECM and the nucleus and this is consistent with our discovery that nuclei contain a tunnel with cytoskeleton bundles connected to the nuclear envelope.
See her TED talk: For decades, researcher Mina Bissell pursued a revolutionary idea — that a cancer cell doesn’t automatically become a tumor, but rather, depends on surrounding cells (its microenvironment) for cues on how to develop. She shares the two key experiments that proved the prevailing wisdom about cancer growth was wrong.
More about Mina Bissel here.

Invited by Thomas Pradeu

– Registration is free but mandatory. If you haven’t done so already, please send an email to Thomas Pradeu.

Details

Date:
21 September 2017
Time:
14 h 00 min - 15 h 00 min
Event Category:
Website:
https://www.immuconcept.org/event/mina-bissel/

Venue

Amphitheatre ISPED
146 rue Léo Saignat
Bordeaux,
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