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Mina Bissell (Berkeley) Why Don’t We Get More Cancer: The tales of ECM and p53 signaling
21 September 2017 | 14 h 00 min - 15 h 00 min
Title: “Why Don’t We Get More Cancer: The tales of ECM and p53 signaling”
I will discuss, the important role of laminin and its receptors in drug resistance and therapy. Our current data connect laminin1 and laminin5 to regulation of p53 and many other transcription factors in physiologically relevant 3D models.
Finally, our current findings indicate a direct mechanical connection between the ECM and the nucleus and this is consistent with our discovery that nuclei contain a tunnel with cytoskeleton bundles connected to the nuclear envelope.
Invited by Thomas Pradeu
– Registration is free but mandatory. If you haven’t done so already, please send an email to Thomas Pradeu.